International Childhood Cancer Cohort Consortium (I4C)

The International Childhood Cancer Cohort Consortium (I4C) is the world’s largest study into childhood cancer, and looks specifically at preventable causes. The innovative study analyses whether factors such as infection and parental age (parental measures); smoking, drug use, diet, environmental chemicals and radiation (occupational, residential and lifestyle exposures); birth size and infection (childhood health measures), and genetics contribute to the risk of cancer in children.

Collaborators have pooled population data and biological specimens from one million pregnant mothers and their babies in cohorts from 10 countries around the world to analyse cancer in children from conception up to the age of 15 years. The I4C currently includes cohorts from Australia, Brazil, China, Denmark, France, Israel, Japan, Norway, the United Kingdom and the United States, with a hope to capture other cohorts in these countries, and also in Korea, in the future.

Data are collected during pregnancy and from the baby well before any cancer occurs in order to build crucial insights into whether, and how, factors contribute to the risk of developing the disease. Important findings are already emerging from the analysis of this pooled data.

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