Background Evidence from randomised controlled trials (RCTs) is vital for enabling healthcare providers and policymakers to make informed decisions about healthcare. RCTs are considered the ‘gold standard’ for evaluating the effectiveness of interventions because they represent the highest level of evidence due to the ability to control bias at multiple levels. The applicability and generalisability of evidence generated in other parts of the world to India has limitations. As such high quality RCTs are required to improve clinical care and build a culture of evidence-based medicines. With resources being limited there is a need to prioritise funding decisions. To inform research prioritisation and science policy related to clinical trials there is a need to understand the landscape of existing randomised controlled trials. Aim To systematically map randomised controlled trials (RCTs) from India Method We will identify published RCTs conducted among Indians, irrespective of the type of i

Background Sharing of clinical trial data to improve transparency and enable data re-analysis is on the rise globally. Individual participant data (IPD) meta-analysis offers an enhanced scope of in-depth analysis, including but not limited to understand how participant-level covariates might affect treatment effects. A key challenge for evidence synthesis specialists conducting IPD meta-analysis is the availability of de-identified participant-level data from clinical trials. Aim To examine how information on individual participant data availability is captured in different clinical trial registries To analyse the intent of individual participant data sharing in records from clinical trial registries Research Methodology We will search for and analyse data related to individual participant data availability in clinical trial registries. Potential Impact The results of the meta-research project will offer information to inform policies to inform the availability of individual partic

Background Snakebite is a neglected tropical disease with almost all its burden being concentrated in South Asia and Africa. Every year 81,000–138,000 people die due to snakebite globally, almost half of them in India. The World Health Organisation has in 2019 developed a strategy to address the burden of snakebite. It has four pillars: empower and engage communities. ensure safe, effective treatment. strengthen health systems. increase partnerships, coordination and resource sharing. While community-based interventions are very common there is no evidence synthesis on the effectiveness of it. The current project fills this gap. Aim To assess the effectiveness of community-based interventions for addressing the burden of snakebite Research Methodology Community based interventions for snakebite represents a complex public health intervention. The project will focus on conduct of a high-quality systematic review of intervention studies, in accordance with broad principles and

BackgroundCOHESION-I, a unique collaborative research initiative, is being implemented across Peru, Mozambique, Nepal, and India. Its primary focus is on understanding and enhancing the responsiveness of health systems. In India, the project takes a distinct approach, targeting the rural communities in the states of Telangana and Chhattisgarh. It will engage local communities in co-designing and implementing strategies to improve access to and utilisation of primary health care services provided by the public health system.The COHESION-I project aims to comprehensively understand primary healthcare responses for tracer conditions such as hypertension and diabetes mellitus for non-communicable diseases (NCDs) and lymphatic filariasis for neglected tropical diseases (NTDs). This research is crucial as it addresses pressing health challenges in low-resource settings, emphasising community engagement and participatory approaches. By focusing on national priorities such as improving primary health care and address