The Meniscal Transplant surgery or Optimised Rehabilitation full randomised trial (MeTeOR2)
BackgroundThe meniscus is a c-shaped knee cartilage structure which distributes force between joint surfaces. Meniscal tears can occur, and often the torn parts are removed with keyhole surgery called arthroscopic partial meniscectomy. In Australia approximately 37,000 meniscectomies were performed between 2020-21, 10% were in young adults (< 30 years). Some people have considerable and persistent pain and impaired function after meniscectomy, and how to best treat this is unknown. Meniscal Allograft Transplant (MAT) is a treatment option where a donor meniscus is implanted into the knee. However, there is a lack of evidence whether this procedure is superior to physiotherapy.AimTo see if MAT surgery or Personalised Knee Therapy (PKT) is the most clinically and or cost-effective treatment, for people with knee pain and/or functional loss after a meniscectomy.Research MethodologyMETEOR2 is a two-armed multi-centred pragmatic, international, randomised controlled trial to assess the cost-effectiven
REVERSE: Reducing cardiovascular and kidney risk in diabetes
Background
Diabetes is a major public health challenge, causing additional complications across multiple organ systems. Cardiovascular disease (CVD) and chronic kidney disease (CKD) are the leading causes of disability and death in people with type 2 diabetes mellitus (T2DM).
In Australia, T2DM prevalence has nearly tripled in recent decades, with around 1.3 million people affected. The condition carries enormous economic and societal costs. T2DM has a major impact in socioeconomically disadvantaged areas like Western Sydney, South-Western Sydney, and regional NSW, where high prevalence and CVD/CKD complications represent major challenges for local health services.
Treatments to slow and prevent the CVD/CKD effects of diabetes exist, but they rely on a health system that can readily identify high-risk patients, implement, and monitor treatment, and coordinate the complex care of such patients. Although proven strategies to delay and prevent the impacts of CVD and CKD in high-risk diabet
Evidence library
Please find below a list of the key publications supporting the case for potassium-enriched salt. For a more comprehensive list, click here or to return to the main page click here.
Trials
Effect of Salt Substitution on Cardiovascular Events and Death.New England Journal of Medicine, 2021https://www.nejm.org/doi/full/10.1056/nejmoa2105675
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial.Nature Medicine, 2023https://www.nature.com/articles/s41591-023-02286-8
Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis.Heart 2022https://heart.bmj.com/content/108/20/1608.long
Effects of a reduced-sodium added-potassium salt substitute on blood pressure in rural Indian hypertensive patients: a randomized, double-blind, controlled trialThe American Journal of Clinical Nutrition, 2021https://www.sciencedirect.com/science/article/pii/S0002916522003185
A guide to potassium-enriched salt
Please find below downloadable one-page guides for consumers and health professionals with key information on potassium-enriched salt.
For health professionalsA guide to potassium-enriched salt.Learn more
For consumersA guide to potassium-enriched salt.Learn more
WHO guidelineA summary for policy makersLearn more
FactsheetSwitching the world’s salt supply: Scaling up the use of potassium-enriched salt.Learn more
For meal producersLearn more
EvidenceUK evidence on using low-sodium salt substitutes.Learn more
Why do we need to #SwitchTheSalt?
Why do we need to #SwitchTheSalt?
Almost everyone eats salt and almost everyone eats too much of it. Eating too much salt increases blood pressure, leading to heart attacks, strokes and deaths. Despite the efforts by governments and medical organisations over the last decade to reduce population salt intakes, little progress has been made. This is because people have become accustomed to the taste and dietary habits are hard to change. Salt is also a widely used ingredient in food manufacturing, and progress towards lowering levels in packaged foods has been slow.
Find out more about our work to scale up the use of potassium-enriched salt across the global food supply.
What is potassium-enriched salt?
Potassium-enriched salt is a practical and scalable approach to lowering blood pressure and with it, the risk of strokes, heart attacks and death. Salt is made up of 100% sodium and chloride. A potassium-enriched salt, however, has some of the harmful sodium chloride replaced wi
