Background Worldwide the leading risk factor for death is raised blood pressure  (BP), accounting for ~30,000 deaths daily.1 In Australia, high BP is responsible for 43% of coronary heart disease, 41% of stroke, 65% of the burden of hypertensive heart disease, 38% of chronic kidney disease, 32% of atrial fibrillation and flutter and 3.6% of dementia.2 Better BP control could save more lives than any other single treatment intervention.3 In Australia, BP control rates have stagnated since 2011 at ~32%,4, 5 leading to a 2022 call to action to improve uncontrolled BP in Australia.5 Hypertension (the condition you have from high BP) is called the "silent killer" because most people who have raised BP do not have any symptoms.6 In Australia, 34% of adults have hypertension,4 but millions remain unaware and undiagnosed.6, 7 Only one in two people detected to have high BP are aware of their condition.8 Innovative strategies to target wider and high-risk populations,

Background Acute Kidney Injury (AKI) affects up to 1 in 2 patients treated in the ICU, and is associated with poorer survival, reductions in long term kidney function and greater cost of treatment. There are no treatments proven to reduce these impacts of AKI but there is a growing evidence base suggesting that inhibitors of the sodium-glucose transport protein 2 (SGLT-2 inhibitors) in the kidney tubule may protect against AKI. SGLT-2 inhibitors were originally developed as a treatment for type 2 diabetes but have been proven in recent clinical trials to significantly improve outcomes for patients with heart disease and/or kidney impairment - with fewer patients progressing to dialysis, needing hospital care or dying. Later examination of these trials has also shown lower rates of AKI in participants receiving SGLT-2 treatment but, as these results were not the main outcome of the studies, these findings are not enough to change patient treatment. Aim To conduct a prospective, multi-centre, parall

Current status– finished recruitment – in follow-up.TRIDENT is an international medical research study which aims to determine the effect of more intensive blood pressure control to prevent recurrent stroke in patients who have had an intracerebral haemorrhage (ICH) (a stroke caused by ruptured blood vessel in the brain). The aim of this project is to test the superiority of a fixed low-dose combination blood pressure-lowering pill (Triple Pill) strategy in recurrent stroke in patients with a history of ICH.Acute ICH accounts for at least 10% of the 20 million new strokes in the world each year. ICH survivors are at high risk of recurrent stroke and other serious cardiovascular events. Numerous studies have proven the benefit of stroke survivors reducing their risk of recurrent stroke through taking blood pressure-lowering medications. However, studies have shown that many ICH survivors are either not receiving any blood pressure-lowering medication or they are receiving inadequate control.The TRIDENT stu

Background Knee replacement improves the quality of life for those suffering from disabling knee osteoarthritis. Physiotherapy is an important component of the rehabilitation phase following surgery for restoring function and improving quality of life. However, poor adherence to physical therapy due to various socio-environmental and patient-related factors delays recovery. A lack of mechanism for the continuum of care following discharge to home leads to sub-optimal outcomes, chronic knee pain and patient dissatisfaction in some proportions of individuals. Evidence suggests that home-based physical rehabilitation with a monitoring mechanism is as good as and cost-effective compared to clinic-based rehabilitation. In India, unsupervised home-based rehabilitation is the usual care, leading to a considerable amount of out-of-pocket expenditure to seek physiotherapist support at home. Hence, keeping the local requirements and literacy level in mind, a customised and context-specific rehabilitation monitori

Background Women who have survived violence experience negative consequences on their sexual and reproductive health, unsafe abortions, sexually transmitted infections, traumatic fistulas, and are twice as likely to be diagnosed with cervical cancer. They also experience anxiety, depression, and alcohol use disorders. Rates of violence against women and gender based discrimination continue to remain high despite legislative action by governments. With COVID-19 pandemic, the situation has become alarming demanding ever more serious action in protecting the rights of women and addressing Gender Based Violence (GBV) and discrimination across the globe. The United Nations (UN) Convention on the Elimination of all Forms of Discrimination Against Women (CEDAW) has been considered as an important instrument towards encouraging governments to take action towards protecting the rights of women and addressing gender based discrimination through legal reforms. It has been 40 years since the United Nations (UN) Con