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The George Institute has a highly skilled team which works to conceptualise, develop, and deliver innovative and impactful clinical trials, characterised by the following features: Reducing trial ‘waste’ Ensuring that clinical trials are efficient is crucial to minimising research ‘waste’, which most commonly results from the costs associated with poorly conceived research questions, inappropriate study design, failure to adequately report on all areas being analysed, and inefficient operational conduct. Trial efficiency can be improved via two key mechanisms- by design and by conduct. Trial design involves the development and application of innovative statistical methods including adaptive and pragmatic designs. The first involves adapting some elements of the design as the trial progresses (rather than waiting for the trial to end). A pragmatic trial evaluates a health intervention in a setting as close as possible to real-world conditions. Adaptive designs help to gener

Working together with consumers and community members helps the Institute achieve high-quality research that has the greatest impact on the health and wellbeing of Australian people. The Institute is guided by the work of peak bodies such as the National Health and Medical Research Council and Consumers Health Forum of Australia. When using the term ‘consumer’, we are referring to patients and potential patients, people who use health care services, and their carers or family members. When we use the term ‘community members’ we refer to those who share an interest in our research – including sub-groups of the Australian population, and healthy members of our community who want to prevent ill-health. Below are key ways that consumers are involved in health research. Consumer and Community Advisory CommitteeThe CCAC oversees consumer involvement at the Institute. The committee works with key staff, including the Executive team and research program leads

At The George Institute, we are committed to improving our research by making it more relevant, responsive, translatable, and accountable to our communities, including patients, consumers, people with lived experiences, carers, civil society groups, and the public. These groups have a right to have a say in what is researched and how, and our aim is to ensure their involvement is a fundamental aspect of all our projects, wherever applicable and feasible. Meaningful involvement ensures that research questions are aligned with community needs, improves the relevance and usefulness of findings, and promotes a sense of ownership and understanding among community members. Additionally, it provides a platform for advocacy and increases the likelihood of research findings being used by policy makers. Ultimately, it empowers communities, fosters equitable partnerships, and drives positive social change. Our Framework for Community Engagement and Involvement was developed to establish a common