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The George Institute for Global Health
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    We are on a mission to improve global health. Through rigorous, high-quality research, we’re striving to achieve meaningful and lasting change on a local and global scale. 
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    Our research finds solutions to some of the world’s biggest health challenges in critical areas including women’s health, planetary health, and food policy. Within each program, individual projects target specific challenges, providing local solutions to improve global outcomes.   
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Sex and gender equity

When it comes to our health the story isn't balanced. But it should be. We are committed to achieving health equity through our sex and gender initiatives. We consider how sex and gender influence health and medical research because it is sound science and promotes the health of everyone. Discover how The George Institute is leading efforts to close the sex and gender health gap in a video by our Founding Director, Prof Robyn Norton, and a blog from our Chair in Global Women’s Health, Prof Jane Hirst. The George Institute's Sex and Gender Initiatives Centre for Sex and Gender EquityThe Centre for Sex and Gender Equity in Health and Medicine brings together researchers across Australia with an interest in the effects of sex and gender on health outcomes.Learn more The MESSAGE ProjectThe Medical Science Sex and Gender Equity project aims to improve the integration of sex and gender considerations in biomedical, health and care research in the United Kin

Improving recovery outcomes for burns survivors in India: a systems approach

Background Globally, burns are a leading cause of disability, with over 8 million years of life lost each year. The burden of burns falls disproportionately on the poorest. It is estimated that 114,000 deaths every year are caused by fire-related injury, the majority of which occur in low- and middle-income countries. In 2019, 23000 fire-related deaths were estimated to burns in India, which is around 20% of the global mortality burden. Around 1.5 million disability-adjusted life years were estimated to be due to fire-related injuries. Burns statistics in India reflect gender and social inequality. Mortality due to burning is three times higher among women aged between 15-49 years, and four times higher among women aged between 15-34 years. The lack of effective quality burns services, and the absence of coordinated efforts within the health system, contribute to high mortality and morbidity rates. The burden of incurring high out-of-pocket costs and catastrophic expenditure for the family is highest in

Produce Prescription: innovative ‘Food is Medicine’ intervention to improve health among people with type 2 diabetes

Background Currently, there is a strong ‘Food is Medicine’ movement evolving, calling for healthy foods or meals to be prescribed by doctors to prevent or treat diet-sensitive conditions, like they already do with drugs. Outcomes from early studies, in which doctors prescribe healthy foods, termed ‘produce prescriptions’, have suggested comparable health benefits to prescription medications. In addition to improving health outcomes, these programs also reduce health inequity by focusing on communities experiencing food insecurity. Unhealthy diet is one of the major drivers of type 2 diabetes that costs Australian healthcare tens of billions of dollars each year and occurring most frequently among the most disadvantaged communities. Our completed pilot study in Australia demonstrated considerable potential benefit of produce prescription for those with type 2 diabetes, and high acceptability among program participants. However, gold-standard randomised trial data are needed to define clinica

TEXT4myBACK: A text message intervention to improve function in people with low back pain

BackgroundResearch findings show that treatments commonly offered to patients with low back pain (LBP) are not evidence-based and are potentially harmful (e.g. opioids or routine imaging).Treatments for LBP, such as medication and bed rest, are often associated with higher disability compared to active management strategies and do not help patients develop self-management skills for their condition. Reviews have shown that most self-management approaches for LBP fail to address key healthy lifestyle behaviours (i.e. weight control, physical activity participation, sleep quality), known to be associated with the risk of developing chronic musculoskeletal pain.The effectiveness of using text messages to educate and empower patients to self-manage their acute LBP through lifestyle-based interventions is currently unknown. The TEXT4myBACK study seeks to answer this important question.AimTo evaluate the effectiveness of a lifestyle-focused intervention delivered by mobile phone text message for adults with no

ANUMATI 2.0: Adolescent resilience-building in urban slums – A multifaceted implementation trial of life skills education in India

Background Adolescence is a period of rapid physical, mental and social change that can be stressful, and which might have an adverse impact on the mental wellbeing of adolescents. Stress and depression in young people are highly correlated with other non-communicable disease (NCD) risk factors such as smoking, alcohol and substance use and physical activity. Adolescents, especially older ones (15-19 years) experience many key transitions such as developing intimate relationships with peers and increasing responsibility in decision-making. Successfully navigating these transitions can reduce stress and NCD risk factors and have a lasting impact on the quality of life right into adulthood. Aim To evaluate the feasibility, clinical effectiveness and cost-effectiveness of two community-based implementation strategies for life skills education among older adolescents with or at high risk of depression.Research MethodologyA life skills education program will be developed to promote physica

Translating Research Findings in Surgery

BackgroundWith the expanding body of clinical knowledge in surgical procedures, driven by evidence-based research and clinician experience, the demand for translating research findings into practice and implementing changes is increasing.The adoption of new techniques and phasing out of old ones in clinical practice can be slow, facing many barriers and significantly impacting patient outcomes.AimTo increase the efficiency and effectiveness of translating research findings into surgical clinical practice by connecting evidence-based research results with surgical clinical practice and ultimately improve patient outcomes.A keystone to the project is working closely with clinicians and a diverse range of experts to identify the barriers and facilitators of translating research findings into practice, ultimately culminating in an implementation framework for surgery.Research MethodologyThe research project will be collaborative in nature, with a four-step approach for developing a useful framework for clinicians

Walking with the low back pain patient: understanding the patient journey

BackgroundLow back pain (LBP) is a major global health issue, affecting 619 million people in 2020—a significant rise from 1990, with numbers expected to increase by another 36% by 2050. LBP is also the leading cause of disability worldwide, affecting people's ability to work and enjoy daily life. Despite clear medical guidelines, there are major differences in the care that people with LBP receive. The 4th Australian Atlas of Healthcare Variation highlights overuse of surgeries, with more than 14,000 lumbar spinal fusions performed between 2015 and 2018. A large review of 195,000 patients from multiple countries, including Australia, found that less than half of LBP patients received the right medications. Beyond medical treatments, people with low back pain often encounter difficulties accessing non-drug therapies and navigating the healthcare system. This makes it harder for patients to get the right care at the right time.AimTo explore the experiences of patients with low back pain through the

CAPTIVATE: Finding treatments to slow the progression of chronic kidney disease

Background Chronic kidney disease (CKD) affects over 800 million people globally and is projected to be the 5th  most common cause of death by 2040. CKD progresses to kidney failure, increases the risk of early death, heart disease, and leads to a poorer quality of life. Current treatments do not entirely remove the risk of kidney failure in people with CKD.  To improve the outcomes of people with CKD, it is crucial to find the best treatments that can slow CKD progression. Aim CAPTIVATE aims to find the best treatment, or combination of treatments, that slow the progression of CKD so that fewer people develop kidney failure.  CAPTIVATE is the first platform trial in CKD and will identify the best treatments for CKD more quickly than with traditional trial designs, thus saving time and money. Research Methodology CAPTIVATE is a multi-centre, phase III, adaptive, platform, randomised controlled trial. It uses a design that can answer many treatment-related questions within a

SUcceSS: SUrgery for Spinal Stenosis – a randomised placebo-controlled trial

Background Lumbar spinal stenosis (LSS) is a common and debilitating condition that primarily affects individuals over 50. It results from degenerative changes in the structures surrounding the spinal canal—such as the intervertebral discs, facet joints, and ligaments—that lead to a narrowing of the central lumbar spinal canal. People with LSS often experience pain, numbness, or weakness in one or both legs, which worsens with standing or walking but is relieved by sitting or bending forward. When symptoms do not improve with conservative treatments like medication or physiotherapy, surgery is often recommended. Decompression surgery, such as a laminectomy or laminotomy, involves removing bone and ligament tissue that contribute to the narrowing of the spinal canal. While some individuals experience symptom relief following surgery, strong evidence supporting the efficacy of this approach is still lacking. Aim This project aims to evaluate the efficacy, safety and cost-effect

FoodSwitch App

FoodSwitch packaged food database empowers you with access to information to help you make informed decisions about what you eat

SuSTAInZ - Supporting Successful Transition to Adult belts In Cars: examining effectiveness of optimiZed tools

BackgroundOptimal crash protection requires the most appropriate restraint for a child’s size. For children <7 years, Australian law dictates the restraint type to be used. For children ≥7 years, parents can choose the restraint that best suits their child, for example using seatbelts or a booster seat. However, current literature suggests that there is confusion about when their children can safely use seatbelts. This stems from the fact that optimal protection from a seatbelt requires a good match between child size and geometry of both the seatbelt and the vehicle seat. Yet there is a wide variation of seatbelt and vehicle seat geometry across different cars. This coupled with intrinsic variations in child size makes it difficult to provide advice using age or height. The result is that many children ≥7 years inappropriately use seatbelts, increasing risk of injury in a crash.Current best practice advice for parents to make transition decisions is the 5-step test. Our recent study shows that the 5

Action on salt China

Salt reduction lowers blood pressure and reduces cardiovascular disease including stroke, heart attack and heart failure. Research has shown that if people reduced their salt intake by 15% it could prevent 8.5 million cardiovascular deaths over 10 years in 23 developing countries and result in major cost savings. The UK has reduced salt by 15% from 2003 to 2011 due to a successful salt reduction program leading by Professor Graham MacGregor, Consensus Action on Salt and Health (CASH). In 2005, WASH (World Action on Salt and Health) was initiated by Professor MacGregor, with a mission of reducing salt globally. WASH has helped many countries develop a salt reduction strategy. Reaching China China is the largest developing country with one fifth of the world’s population. Due to Chinese traditional cooking and dining habits, salt intake in China is very high and about 80% of the salt is added by the consumer to food. Hypertension and strokes which are often directly related to high salt intake are among

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    The George Institute acknowledges First Peoples and the Traditional Custodians of the many lands upon which we live and work. We pay our respects to Elders past and present, and thank them for ongoing custodianship of waters, lands and skies.

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    The George Institute for Global Health is proud to work in partnership with UNSW Sydney, Imperial College London and the Manipal Academy of Higher Education, India.

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