Background Stroke remains a leading cause of death and disability worldwide. Despite advances in medical technology and treatment strategies, many patients still do not achieve optimal outcomes. The George Institute’s ACT-GLOBAL study is an adaptive platform trial that is aiming to address the urgent need for the development of new and more effective interventions for stroke patients across the world. A platform trial involves study of several different clinical questions at the same time, essentially uniting multiple clinical trials or ‘Domains’ under a single organisational structure lead by experts in the field. Adaptive design allows the team to add or collapse (if needed) research questions during the trial as more information is collected. We believe the adaptive platform approach is a uniquely flexible and efficient way to conduct ground-breaking research. The ACT-GLOBAL platform currently has several domains across the stroke-subtypes of Acute Ischemic Stroke, where a bloc