Clinical and community trials
About this study
People with advanced kidney disease or those receiving dialysis often have other diseases related to the heart, brain and blood vessels, known as vascular disease (for example, heart attack, stroke and poor blood circulation). However, few treatments have been proven to prevent these conditions in people with advanced kidney disease. Blood thinners (medicines that prevent blood clots) are frequently used and proven to help other groups of people who are at high risk of vascular disease.
There is little understanding of whether blood thinners provide similar benefits in people with advanced kidney disease. The aim of the TRACK study is to find out whether a low dose of blood thinning medicine can reduce heart and vascular disease better than placebo (a look alike tablet that contains no active medication) in people with advanced kidney disease.
Recruitment criteria
Inclusion:
Age ≥18 years,
Advanced kidney disease (kidney failure on dialysis, or
Join Us: Strengthening Australia’s research capability
Background
Australia is a world leader in health and medical research, however an ongoing research barrier is the slow recruitment of research participants across the country.
Increasing community involvement in medical research is a key goal for the government’s “National One Stop Shop” for clinical trials.
Research registers are a proven way of connecting patients and researchers, but these registers typically address specific diseases, focus on people attending metropolitan centres of excellence, and can be difficult for patients to navigate.
Disease-agnostic research registers offer participants of all types a single point of access to research.
Aims
Join Us is a not-for-profit, disease-agnostic health research register dedicated to connecting everyday Australians with meaningful research opportunities.
Join Us aims to achieve better health and wellbeing for the Australian community by removing a major barrier to the recruitment of participant
Point Prevalence Program
The Point Prevalence Program (PPP) is a collaborative project between Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG) and the Critical Care Division of The George Institute.
Aim
As a coordinated and validated project , the Point Prevalence Program provides infrastructure to conduct several multi-centre observational studies simultaneously on specified study days each year. The impetus for the PPP is to improve the efficiency of the collection of observational data that helps design clinical trial protocols for future ANZICS CTG studies. A further use of the PPP is that it can help with generating data to understand how research findings are translated into clinical practice.
Significance
The program facilitates collaborations amongst members of the CTG with an average of 44 ICUs participating each study day from a range of tertiary, metropolitan, regional-rural and private hospitals with an average recruitment per study day of more than 550 participants.
Intensive Insulin Therapy Trialists' Collaboration (IIT-TC)
Hyperglycaemia is a common finding in patients who are acutely ill even in the absence of a prior diagnosis of diabetes mellitus. In acutely ill patients, hyperglycaemia is associated with a worse outcome.
As hyperglycaemia is consistently associated with increased morbidity and mortality, critical care researchers have conducted a number of trials to investigate whether tighter control of blood glucose in critically ill patients is beneficial. To date there have been over 30 randomised controlled trials of tight glucose control in critical care settings.
However, many studies have reported non-significant results; in part this is because many of the trials were small and when considered alone had insufficient statistical power to examine the effects of tight glucose control on mortality.
Aims
The aim of this collaborative research project is to combine the individual patient data from all randomized controlled trials of tight glucose control in critically ill adults around the world to conduct
Changes in clinical guidelines for the management of chronic back pain
Policy & Practice Report
Improving the management of stroke
Policy & Practice Report
Australian Government Preventative Health Taskforce
Policy & Practice Report
Developing renal service plans
Policy & Practice Report
Assessment of absolute cardiovascular disease risk
Policy & Practice Report
Addressing chronic disease among indigenous Australians
Policy & Practice Report
Informing treatments for patients with type 2 diabetes
Policy & Practice Report
Seamless User-centred Proactive Provision Of Risk-stratified Treatment in Peritoneal Dialysis (SUPPORT-PD)
Project aims to develop an integrated, patient-centred, affordable and sustainable system for proactive management of patients undergoing peritoneal dialysis based on patients’ needs using innovative technologies and methodologies for service design
Methods
This is an observational cohort study which aims to develop a user-friendly and functional IT supported system for education and monitoring of patients undergoing peritoneal dialysis in their homes. We intend to collect information on physiological measures through different sensors in order to be able to compare and ascertain which methods are most acceptable to patients and providers.
Study sites
Postgraduate Institute of Medical Education and Research, Chandigarh and Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow.
Current status
The prototype Mobile Application is being tested