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Health-related Quality of Life in Survivors of Acute Kidney Injury: the Post-RENAL Study Outcomes

TitleHealth-related Quality of Life in Survivors of Acute Kidney Injury: the Post-RENAL Study Outcomes
Publication TypeJournal Article
Year of Publication2015
AuthorsWang, A, Bellomo, R, Cass, A, Finfer, S, Gattas, D, Myburgh, J, Chadban, S, Hirakawa, Y, Ninomiya, T, Li, Q, Barzi, F, Sukkar, L, Jardine, M, Gallagher, M
JournalNephrology (Carlton)
Volume20
Pagination492-8
Date Published04/2015
ISBN Number1440-1797 (Electronic)<br/>1320-5358 (Linking)
Accession Number25891297
Abstract

AIM: Whilst patients with chronic kidney disease have reduced health-related quality of life (HRQOL), long-term HRQOL of survivors of severe acute kidney injury (AKI) remains unclear. METHODS: We analysed HRQOL from the Prolonged Outcomes Study of the Randomised Evaluation of Normal vs. Augmented Level Replacement Therapy (POST-RENAL) study and compared findings with those from a general Australian adult population enrolled in the Australian Diabetes, Obesity and Lifestyle (AusDiab) study. We used a multivariate analysis adjusted for baseline characteristics along with sensitivity analysis using age and sex- matched case controls. RESULTS: In the POST-RENAL study 282 participants had HRQOL data collected using the SF-12 questionnaire. This was compared with 6330 participants from the AusDiab study. Unadjusted analyses showed that POST-RENAL participants had lower physical component scores (PCS, mean score 40.0 vs. 49.8, P<0.0001) and lower mental component scores (MCS, mean score 49.8 vs. 53.9, P<0.0001) than the AusDiab group. After age and sex matching, the difference in PCS and MCS remained statistically significant (P<0.0001). Advanced age, reduced renal function and albuminuria (all P

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