|Title||Effectiveness of fixed dose combination medication ('polypills') compared with usual care in patients with cardiovascular disease or at high risk: A prospective, individual patient data meta-analysis of 3140 patients in six countries|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Webster, RJ, Patel, A, Selak, V, Billot, L, Bots, ML, Brown, A, Bullen, C, Cass, A, Crengle, S, C. Elley, R, Grobbee, DE, Neal, B, Peiris, DP, Poulter, N, Prabhakaran, D, Rafter, N, Stanton, A, Stepien, S, Thom, S, Usherwood, T, Wadham, A, Rodgers, A|
|Journal||International Journal of Cardiology|
|ISBN Number||1874-1754 (Electronic)<br/>0167-5273 (Linking)|
AIMS: To conduct a prospective, individual participant data (IPD) meta-analysis of randomised controlled trials comparing a polypill-based approach with usual care in high risk individuals. METHODS AND RESULTS: Three trials comparing polypill-based care with usual care in individuals with CVD or high calculated cardiovascular risk contributed IPD. Primary outcomes were self-reported adherence to combination therapy (anti-platelet, statin and >/=two blood pressure (BP) lowering agents), and difference in mean systolic BP (SBP) and LDL-cholesterol at 12months. Analyses used random effects models. Among 3140 patients from Australia, England, India, Ireland, New Zealand and The Netherlands (75% male, mean age 62years), median follow-up was 15months. At baseline, 84%, 87% and 61% respectively were taking a statin, anti-platelet agent and at least two BP lowering agents. At 12months, compared to usual care, participants in the polypill arm had higher adherence to combination therapy (80% vs. 50%, RR 1.58; 95% CI, 1.32 to 1.90; p<0.001), lower SBP (-2.5mmHg; 95% CI, -4.5 to -0.4; p=0.02) and lower LDL-cholesterol (-0.1mmol/L; 95% CI, -0.2 to 0.0; p=0.04). Baseline treatment levels were a major effect modifier for adherence and SBP (p-homog <0.0001 and 0.02 respectively) with greatest improvements seen among those under-treated at baseline. CONCLUSIONS: Polypill therapy significantly improved adherence, SBP and LDL-cholesterol in high risk patients compared with usual care, especially among those who were under-treated at baseline.
Effectiveness of fixed dose combination medication ('polypills') compared with usual care in patients with cardiovascular disease or at high risk: A prospective, individual patient data meta-analysis of 3140 patients in six countries