TY - JOUR AU - Finfer Simon AU - Hirakawa Y. AU - Bellomo R. AU - Barzi F. AU - Wang A. AU - Ninomiya T. AU - Cass A. AU - Li Q. AU - Gallagher M. AU - Gattas D. AU - Myburgh J AU - Chadban S. AU - Jardine M AU - Sukkar L. AB -

AIM: Whilst patients with chronic kidney disease have reduced health-related quality of life (HRQOL), long-term HRQOL of survivors of severe acute kidney injury (AKI) remains unclear. METHODS: We analysed HRQOL from the Prolonged Outcomes Study of the Randomised Evaluation of Normal vs. Augmented Level Replacement Therapy (POST-RENAL) study and compared findings with those from a general Australian adult population enrolled in the Australian Diabetes, Obesity and Lifestyle (AusDiab) study. We used a multivariate analysis adjusted for baseline characteristics along with sensitivity analysis using age and sex- matched case controls. RESULTS: In the POST-RENAL study 282 participants had HRQOL data collected using the SF-12 questionnaire. This was compared with 6330 participants from the AusDiab study. Unadjusted analyses showed that POST-RENAL participants had lower physical component scores (PCS, mean score 40.0 vs. 49.8, P<0.0001) and lower mental component scores (MCS, mean score 49.8 vs. 53.9, P<0.0001) than the AusDiab group. After age and sex matching, the difference in PCS and MCS remained statistically significant (P<0.0001). Advanced age, reduced renal function and albuminuria (all P

AD - The George Institute for Global Health, Camperdown, Australia; The University of Sydney, Australia. AN - 25891297 BT - Nephrology (Carlton) DP - NLM ET - 2015/04/22 LA - Eng LB - R&M
CCT M1 - 7 N1 - Wang, Amanda Y
Bellomo, Rinaldo
Cass, Alan
Finfer, Simon
Gattas, David
Myburgh, John
Chadban, Steve
Hirakawa, Yoichiro
Ninomiya, Toshiharu
Li, Qiang
Lo, Serigne
Barzi, Federica
Sukkar, Louisa
Jardine, Meg
Gallagher, Martin
POST-RENAL Study Investigators and the ANZICS Clinical Trials Group
Nephrology (Carlton). 2015 Apr 19. doi: 10.1111/nep.12488. N2 -

AIM: Whilst patients with chronic kidney disease have reduced health-related quality of life (HRQOL), long-term HRQOL of survivors of severe acute kidney injury (AKI) remains unclear. METHODS: We analysed HRQOL from the Prolonged Outcomes Study of the Randomised Evaluation of Normal vs. Augmented Level Replacement Therapy (POST-RENAL) study and compared findings with those from a general Australian adult population enrolled in the Australian Diabetes, Obesity and Lifestyle (AusDiab) study. We used a multivariate analysis adjusted for baseline characteristics along with sensitivity analysis using age and sex- matched case controls. RESULTS: In the POST-RENAL study 282 participants had HRQOL data collected using the SF-12 questionnaire. This was compared with 6330 participants from the AusDiab study. Unadjusted analyses showed that POST-RENAL participants had lower physical component scores (PCS, mean score 40.0 vs. 49.8, P<0.0001) and lower mental component scores (MCS, mean score 49.8 vs. 53.9, P<0.0001) than the AusDiab group. After age and sex matching, the difference in PCS and MCS remained statistically significant (P<0.0001). Advanced age, reduced renal function and albuminuria (all P

PY - 2015 SN - 1440-1797 (Electronic)
1320-5358 (Linking) SP - 492 EP - 8 T2 - Nephrology (Carlton) TI - Health-related Quality of Life in Survivors of Acute Kidney Injury: the Post-RENAL Study Outcomes VL - 20 ER -