01629nas a2200169   4500000000100000008004100001260001700042100001200059700001900071700001400090245009500104250001500199300000700214490000700221520118500228020004601413       2016                            d  c1692990863831 aSato S.1 aAnderson Craig1 aCarcel C.00aBlood Pressure Management in Intracranial Hemorrhage: Current Challenges and Opportunities  a2016/02/26  a220 v183 a<p>
OPINION STATEMENT: Non-traumatic intracranial hemorrhage (i.e. intracerebral hemorrhage [ICH] and subarachnoid hemorrhage [SAH]) are more life threatening and least treatable despite being less common than ischemic stroke. Elevated blood pressure (BP) is a strong predictor of poor outcome in both ICH and SAH. Data from a landmark clinical trial INTERACT 2, wherein 2839 participants enrolled with spontaneous ICH were randomly assigned to receive intensive (target systolic BP &lt;140 mmHg) or guideline recommended BP lowering therapy (target systolic BP &lt;180 mmHg), showed that intensive BP lowering was safe, and more favorable functional outcome and better overall health-related quality of life were seen in survivors in the intensive treatment group. These results contributed to the shift in European and American guidelines towards more aggressive early management of elevated BP in ICH. In contrast, the treatment of BP in SAH is less well defined and more complex. Although there is consensus that hypertension needs to be controlled to prevent rebleeding in the acute setting, induced hypertension in the later stages of SAH has questionable benefits.
</p>
  a1092-8464 (Print)<br/>1092-8464 (Linking)