02435nas a2200205   4500000000100000008004100001100001500042700001400057700001700071700001400088700001100102700001900113700001300132245013100145250001500276300001100291490000700302520187400309020004602183       2010                            d1 aSobngwi E.1 aMbanya J.1 aKengne Andre1 aBalkau B.1 aVol S.1 aDucimetiere P.1 aFezeu L.00aWaist circumference and obesity-related abnormalities in French and Cameroonian adults: the role of urbanization and ethnicity  a2010/01/13  a446-530 v343 a<p>
OBJECTIVES: To evaluate the effect of urbanization and ethnicity on correlations between waist circumference (WC) and obesity-related cardiovascular risk factors. METHODS: 1471 rural and urban Cameroonians, and 4185 French, from community-based studies, aged &gt; or =25 years, not treated for hypertension, diabetes and dyslipidemia participated in this study. Slopes of obesity-related abnormalities with WC were compared using an interaction term between place of residence and WC. RESULTS: Women in urban Cameroon and men in France had significantly higher WC and BMI relative to their gender counterparts. Urban Cameroonians had higher abdominal adiposity, but lower BP and better metabolic profile than the French. WC was positively associated to all the obesity-related abnormalities in the three sites except to FPG (both genders) and blood lipids (women) in rural Cameroon. A 5 cm larger WC was associated with a higher increment among urban than rural Cameroonians for diastolic blood pressure (DBP) (women, 1.95/0.63 mm Hg; men, 2.56/1.44 mm Hg), HOMA-IR (women, 0.11/0.05), fasting plasma glucose (FPG) (men, 0.09/-0.01 mmol/l) and triglycerides (women, 0.06/0.01 mmol/l; men, 0.09/0.03 mmol/l), all P&lt;0.05. A 5 cm larger WC was associated with a higher increment among urban Cameroon than French people for DBP (women, 1.95/1.28 mm Hg, P&lt;0.01; men, 2.56/1.49 mm Hg, P&lt;0.01), but with a lower increment for HOMA-IR (women, 0.11/0.14, P&lt;0.05), FPG (women, 0.05/0.09 mmol/l), total cholesterol (women, 0.07/0.11 mmol/l; men, 0.10/0.13 mmol/l) and triglycerides (women, 0.06/0.11 mmol/l; men, 0.09/0.13 mmol/l) all P&lt;0.05. CONCLUSION: Ethnicity and urbanization modify the association of WC with obesity-related metabolic abnormalities. WC cutoff points derived from Caucasians may not be appropriate for black Sub-Saharan Africans.
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