@article{22453,
  author = {van der Schouw Y. and Butterworth A. and Wennberg P. and Di Angelantonio E. and Danesh J. and Moons K. and Lassale C. and Wood A. and Thompson S. and Matullo G. and Peters S. and Arriola L. and Boeing H. and Clavel-Chapelon F. and Key T. and Overvad K. and Panico S. and Tjonneland A. and Tumino R. and Riboli E. and Wareham N. and Weiderpass E. and Sweeting M. and Benetou V. and Bonnet F. and Butt S. and Drake I. and Gavrila D. and Klinaki E. and Krogh V. and Kuhn T. and Masala G. and Merritt M. and Molina-Portillo E. and Moreno-Iribas C. and Nost T. and Olsen A. and Onland-Moret N. and Redondo M. and Trichopoulou A. and Turzanski-Fortner R. and Tzoulaki I. and Winkvist A.},
  title = {Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study},
  abstract = {<p>
OBJECTIVE: There is uncertainty about the direction and magnitude of the associations between parity, breastfeeding and the risk of coronary heart disease (CHD). We examined the separate and combined associations of parity and breastfeeding practices with the incidence of CHD later in life among women in a large, pan-European cohort study. METHODS: Data were used from European Prospective Investigation into Cancer and Nutrition (EPIC)-CVD, a case-cohort study nested within the EPIC prospective study of 520,000 participants from 10 countries. Information on reproductive history was available for 14,917 women, including 5138 incident cases of CHD. Using Prentice-weighted Cox regression separately for each country followed by a random-effects meta-analysis, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD, after adjustment for age, study centre and several socioeconomic and biological risk factors. RESULTS: Compared with nulliparous women, the adjusted HR was 1.19 (95% CI: 1.01-1.41) among parous women; HRs were higher among women with more children (e.g., adjusted HR: 1.95 (95% CI: 1.19-3.20) for women with five or more children). Compared with women who did not breastfeed, the adjusted HR was 0.71 (95% CI: 0.52-0.98) among women who breastfed. For childbearing women who never breastfed, the adjusted HR was 1.58 (95% CI: 1.09-2.30) compared with nulliparous women, whereas for childbearing women who breastfed, the adjusted HR was 1.19 (95% CI: 0.99-1.43). CONCLUSION: Having more children was associated with a higher risk of CHD later in life, whereas breastfeeding was associated with a lower CHD risk. Women who both had children and breastfed did have a non-significantly higher risk of CHD.
</p>
},
  year = {2016},
  journal = {European Journal of Preventive Cardiology},
  edition = {2016/07/06},
  isbn = {2047-4881 (Electronic)<br/>2047-4873 (Linking)},
  note = {Peters, Sanne Ae<br/>van der Schouw, Yvonne T<br/>Wood, Angela M<br/>Sweeting, Michael J<br/>Moons, Karel Gm<br/>Weiderpass, Elisabete<br/>Arriola, Larraitz<br/>Benetou, Vassiliki<br/>Boeing, Heiner<br/>Bonnet, Fabrice<br/>Butt, Salma T<br/>Clavel-Chapelon, Francoise<br/>Drake, Isabel<br/>Gavrila, Diana<br/>Key, Timothy J<br/>Klinaki, Eleni<br/>Krogh, Vittorio<br/>Kuhn, Tilman<br/>Lassale, Camille<br/>Masala, Giovanna<br/>Matullo, Giuseppe<br/>Merritt, Melissa<br/>Molina-Portillo, Elena<br/>Moreno-Iribas, Conchi<br/>Nost, Therese H<br/>Olsen, Anja<br/>Onland-Moret, N Charlotte<br/>Overvad, Kim<br/>Panico, Salvatore<br/>Redondo, M Luisa<br/>Tjonneland, Anne<br/>Trichopoulou, Antonia<br/>Tumino, Rosario<br/>Turzanski-Fortner, Renee<br/>Tzoulaki, Ioanna<br/>Wennberg, Patrik<br/>Winkvist, Anna<br/>Thompson, Simon G<br/>Di Angelantonio, Emanuele<br/>Riboli, Elio<br/>Wareham, Nicholas J<br/>Danesh, John<br/>Butterworth, Adam S<br/>Eur J Prev Cardiol. 2016 Jul 4. pii: 2047487316658571.},
  language = {Eng},
}