@article{22127,
  author = {Finfer Simon and Ranieri V. and Rhodes A. and Angus D. and Yende S. and Austin S. and Opal S. and Thompson T. and Bozza F. and LaRosa S.},
  title = {Long-Term Quality of Life Among Survivors of Severe Sepsis: Analyses of Two International Trials},
  abstract = {<p>
OBJECTIVES: To describe the quality of life among sepsis survivors. DESIGN: Secondary analyses of two international, randomized clinical trials (A Controlled Comparison of Eritoran and placebo in patients with Severe Sepsis [derivation cohort] and PROWESS-SHOCK [validation cohort]). SETTING: ICUs in North and South America, Europe, Africa, Asia, and Australia. PATIENTS: Adults with severe sepsis. We analyzed only patients who were functional and living at home without help before sepsis hospitalization (n = 1,143 and 987 from A Controlled Comparison of Eritoran and placebo in patients with Severe Sepsis and PROWESS-SHOCK, respectively). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: In A Controlled Comparison of Eritoran and placebo in patients with Severe Sepsis and PROWESS-SHOCK, the average age of patients living at home independently was 63 and 61 years; 400 (34.9%) and 298 (30.2%) died by 6 months. In A Controlled Comparison of Eritoran and placebo in patients with Severe Sepsis, 580 patients had a quality of life measured using EQ-5D at 6 months. Of these, 41.6% could not live independently (22.7% were home but required help, 5.1% were in nursing home or rehabilitation facilities, and 5.3% were in acute care hospitals). Poor quality of life at 6 months, as evidenced by problems in mobility, usual activities, and self-care domains were reported in 37.4%, 43.7%, and 20.5%, respectively, and the high incidence of poor quality of life was also seen in patients in PROWESS-SHOCK. Over 45% of patients with mobility and self-care problems at 6 months in A Controlled Comparison of Eritoran and placebo in patients with Severe Sepsis died or reported persistent problems at 1 year. CONCLUSIONS: Among individuals enrolled in a clinical trial who lived independently prior to severe sepsis, one third had died and of those who survived, a further one third had not returned to independent living by 6 months. Both mortality and quality of life should be considered when designing new interventions and considering endpoints for sepsis trials.
</p>
},
  year = {2016},
  journal = {Critical Care Medicine},
  edition = {2016/03/19},
  isbn = {1530-0293 (Electronic)<br/>0090-3493 (Linking)},
  note = {Yende, Sachin<br/>Austin, Shamly<br/>Rhodes, Andrew<br/>Finfer, Simon<br/>Opal, Steven<br/>Thompson, Taylor<br/>Bozza, Fernando A<br/>LaRosa, Steven P<br/>Ranieri, V Marco<br/>Angus, Derek C<br/>Crit Care Med. 2016 Mar 17.},
  language = {Eng},
}