00899nas a2200133   4500000000100000008004100001100000500042245006200047250001500109300000800124490000700132520058000139020004600719       2010                            d1 a00aNorepinephrine: more of a neurohormone than a vasopressor  a2010/09/24  a1960 v143 a<p>
Septic shock causes unpredictable cardiovascular responses through adrenoreceptor-mediated changes in cardiac function and vascular responsiveness. The use of norepinephrine should be regarded as neurohormonal augmentation therapy to defend decompensating haemodynamic function rather than as a rescue therapy to treat shock. Recent trials represent a perceptible change in clinical practice to preferentially use norepinephrine early in resuscitation to defend the mean arterial pressure and to use norepinephrine as a neurohormone rather than as a vasopressor.
</p>
  a1466-609X (Electronic)1364-8535 (Linking)