@article{22950,
  author = {Islam Sheikh and Feng Zhe and Li Hua-Long and Bei Wei-Jie and Guo Xiao-Sheng and Wang Kun and Yi Shi-Xin and Luo De-Mou and da Li Xi- and Chen Shi-Qun and Ran Peng and Chen Peng-Yuan and Chen Ji-Yan and Liu Yong and Zhou Ying-Ling},
  title = {Association of lipoprotein(a) with long-term mortality following coronary angiography or percutaneous coronary intervention.},
  abstract = {<p>
<b>BACKGROUND: </b>There is no consistent evidence to suggest the association of plasma lipoprotein(a) (Lp[a]) with long-term mortality in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI).
</p>

<p>
<b>HYPOTHESIS: </b>Level of Lp(a) is associated with long-term mortality following CAG or PCI.
</p>

<p>
<b>METHODS: </b>We enrolled 1684 patients with plasma Lp(a) data undergoing CAG or PCI between April 2009 and December 2013. The patients were divided into 2 groups: a low-Lp(a) group (Lp[a] &lt;16.0 mg/dL; n = 842) and a high-Lp(a) group (Lp[a] ≥16.0 mg/dL; n = 842).
</p>

<p>
<b>RESULTS: </b>In-hospital mortality was not significantly different between the high and low Lp(a) groups (0.8% vs 0.5%, respectively; P = 0.364). During the median follow-up period of 1.95 years, the high-Lp(a) group had a higher long-term mortality than did the low-Lp(a) group (5.8% vs 2.5%, respectively; P = 0.003). After adjustment of confounders, multivariate Cox regression analysis revealed that a higher Lp(a) level was an independent predictor of long-term mortality (hazard ratio: 1.96, 95% confidence interval: 1.07-3.59, P = 0.029).
</p>

<p>
<b>CONCLUSIONS: </b>Our data suggested that an elevated Lp(a) level was significantly associated with long-term mortality following CAG or PCI. However, additional larger multicenter studies will be required to investigate the predictive value of Lp(a) levels and evaluate the benefit of controlling Lp(a) levels for patients undergoing CAG or PCI.
</p>
},
  year = {2017},
  journal = {Clin Cardiol},
  issn = {1932-8737},
  doi = {10.1002/clc.22712},
  language = {eng},
}