@article{22068,
  author = {Kanetsky P. and Dwyer T and Orlow I. and Luo L. and Kricker A. and Armstrong B. and Anton-Culver H. and Gruber S. and Marrett L. and Gallagher R. and Zanetti R. and Rosso S. and Begg C. and Berwick M. and Thomas N. and Reiner A. and Paine S. and Roy P. and Busam K.},
  title = {Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study},
  abstract = {<p>
Factors known to affect melanoma survival include age at presentation, sex and tumor characteristics. Polymorphisms also appear to modulate survival following diagnosis. Result from other studies suggest that vitamin D receptor (VDR) polymorphisms (SNPs) impact survival in patients with glioma, renal cell carcinoma, lung, breast, prostate and other cancers; however, a comprehensive study of VDR polymorphisms and melanoma-specific survival is lacking. We aimed to investigate whether VDR genetic variation influences survival in patients with cutaneous melanoma. The analysis involved 3566 incident single and multiple primary melanoma cases enrolled in the international population-based Genes, Environment, and Melanoma Study. Melanoma-specific survival outcomes were calculated for each of 38 VDR SNPs using a competing risk analysis after adjustment for covariates. There were 254 (7.1%) deaths due to melanoma during the median 7.6 years follow-up period. VDR SNPs rs7299460, rs3782905, rs2239182, rs12370156, rs2238140, rs7305032, rs1544410 (BsmI) and rs731236 (TaqI) each had a statistically significant (trend P values &lt; 0.05) association with melanoma-specific survival in multivariate analysis. One functional SNP (rs2239182) remained significant after adjustment for multiple testing using the Monte Carlo method. None of the SNPs associated with survival were significantly associated with Breslow thickness, ulceration or mitosis. These results suggest that the VDR gene may influence survival from melanoma, although the mechanism by which VDR exerts its effect does not seem driven by tumor aggressiveness. Further investigations are needed to confirm our results and to understand the relationship between VDR and survival in the combined context of tumor and host characteristics.
</p>
},
  year = {2016},
  journal = {Carcinogenesis},
  volume = {37},
  edition = {2015/11/02},
  number = {1},
  pages = {30-8},
  month = {93625559517},
  isbn = {1460-2180 (Electronic)<br/>0143-3334 (Linking)},
  note = {Orlow, Irene<br/>Reiner, Anne S<br/>Thomas, Nancy E<br/>Roy, Pampa<br/>Kanetsky, Peter A<br/>Luo, Li<br/>Paine, Susan<br/>Armstrong, Bruce K<br/>Kricker, Anne<br/>Marrett, Loraine D<br/>Rosso, Stefano<br/>Zanetti, Roberto<br/>Gruber, Stephen B<br/>Anton-Culver, Hoda<br/>Gallagher, Richard P<br/>Dwyer, Terence<br/>Busam, Klaus<br/>Begg, Colin B<br/>Berwick, Marianne<br/>GEM Study Group<br/>P30 CA008748/CA/NCI NIH HHS/United States<br/>R01 CA112243/CA/NCI NIH HHS/United States<br/>R01 CA112524/CA/NCI NIH HHS/United States<br/>U01 CA083180/CA/NCI NIH HHS/United States<br/>UL1 TR001449/TR/NCATS NIH HHS/United States<br/>England<br/>Carcinogenesis. 2016 Jan;37(1):30-8. doi: 10.1093/carcin/bgv157. Epub 2015 Oct 31.},
  language = {eng},
}